Gangadharan Nagendra learnt Carnatic vocal music from Pon Suntharalingam and then from Yalpanam Sri A K Karunakaran. Later he learnt Carnatic Flute from his father Dr. Tiyagaraja Gangadharan. Nagendra is an avid music lover and as a hobby, he makes music instruments. In 1986 he built a Tanpura and a Talometer. Since then he has been experimenting with Carnatic Flutes (Venu) made out of various kinds of materials to produce perfectly tuned clear and crisp notes.